Healthcare and Medicine Reference
In-Depth Information
21
Clinical Application of Noninvasive Molecular
Imaging in Cancer Cell Therapy: The First
Reporter Ge ne-Based Imaging Clinical Trial
Shahriar S. Yaghoubi and Sanjiv S. Gambhir
CONTENTS
21.1 Introduction: Whole-Body Therapeutic Cell Pharmacokinetic
Analysis through Noninvasive Molecular Imaging............................. 369
21.2 Imaging the Survival of Therapeutic Cells: The First Reporter
Gene-Based Therapeutic Cell Imaging Clinical Trial........................... 373
21.2.1 Herpes Simplex Virus Type 1 Thymidine Kinase and
18 F-FHBG ......................................................................................... 373
21.2.2 The Patients..................................................................................... 374
21.2.2.1 Inclusion Criteria for Study Enrollment ...................... 377
12.2.2.2 Exclusion Criteria for Study Enrollment ..................... 378
21.2.3 Preparation and Administration of Genetically
Engineered Autologous Cytolytic T Cells for Cellular
Immunotherapy of Glioma........................................................... 378
21.2.4 Discussion of Positron Emission Tomography Image
Results ............................................................................................. 379
21.3 Future Directions ....................................................................................... 382
References............................................................................................................. 385
21.1 Introduction: Whole-Body Therapeutic
Cell Pharmacokinetic Analysis through
Noninvasive Molecular Imaging
There are three currently conceived techniques for noninvasively imag-
ing the pharmacokinetics of therapeutic cells (TCs) in humans ( Table 21.1 ).
Pharmacokinetics includes the locations, quantity at a specific location,
viability of the TCs, proliferation, and changes in the characteristics of the
 
Search Pocayo ::




Custom Search