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isolated retina
electrode array
02468
mins
B
Spatial pattern of retinal activity in the mouse
P9
P11
P15
0
4
8
12
16
20
24
28
Time (sec)
C
Spatial pattern of cortical activity in the rat
caudal
rostral
fluorescent neurons
Position
FIGURE 9.21 Spontaneous activity in the developing visual pathway. Retinal explants are obtained from
neonatal ferrets and placed on an array of electrodes to record bursts of spontaneous activity from several
retinal locations at the same time. (For clarity, only three locations are shown.) These bursts of activity move
across the retina, as shown by the increasing response latency in each oscilloscope trace (right). B. Electrode
array recordings are plotted for mouse retina at three postnatal ages (P9, P11, and P15). Each square shows
the spatial pattern of activity across the two dimensions of the flattened retinal, with circles representing indi-
vidual neurons. By P15, the spontaneous activity no longer travels across the retina. The spatial activity pat-
terns were acquired every 4 s. C. To observe spontaneous activity in the cortex, brain slices are obtained from
rats during the first postnatal week, and intracellular calcium is imaged using a Ca-sensitive dye (left). Waves
of spontaneous activity sweeps across the cortex from caudal to rostral. (Adapted from Meister et al., 1991;
Demas et al., 2003; Garaschuk et al., 2000)
 
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