Healthcare and Medicine Reference
In-Depth Information
A
Visual Cortex
Thalamus
Eye
Cortex: eye-specific stripes
Layers I-III
Layer IV
Layers V-VI
Thalmus: eye-specific layers
3 H-proline
chiasm
Eye
B
Flat mount
Cross section
P7
P22
P15
P39
P21
P92
FIGURE 9.5 Thalamic afferents form eye-specific terminal zones in cat primary visual cortex. A. When
3 H-proline is injected into one eye, it is transported transynaptically to the cortex. A schematic shows the
visual pathway from eye to cortex. Retinal ganglion cells project to an eye-specific layer in the thalamus, and
thalamic neurons project to eye-specific stripes in cortex Layer IV. B. Autoradiograms of 3 H-proline in post-
natal cat visual cortex show that the terminal field from one eye initially spreads across the entirety of Layer
IV (7 days. left) but gradually becomes restricted to stripes. The left-hand column of images was obtained by
flat mounting the entire cortex and looking down on the surface of Layer IV. This technique provides greater
sensitivity as compared to the individual coronal sections (right-hand column) through the cortex. (Adapted
from LeVay et al., 1978; Crair et al., 2001)
 
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