Healthcare and Medicine Reference
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Figure 1 This fi gure shows the surgical view of a paracentral corneal perforation due to a
herpetic keratitis sealed with cyanoacrylate and a plastic shell before the contact lens fi tting.
Note the air bubble centred due to supine position.
Color image of this figure appears in the color plate section at the end of the topic.
degradation does not lead to toxic metabolites but occurs much more quickly
with possible desirable or undesirable effects.
Additionally, they have useful applications such as to minimize the
use of sutures, improve hemostasis of the conjunctiva and underlying
tissues, and promote adhesion of a mucosal graft or amniotic membrane
(Kaufman et al. 2003).
Limitations of fi brin glues still remain, because this blood product uses
human thrombin and still carries a risk of infection from a contaminated
donor pool (Atrah 1994, Cederholm-Williams 1994, Radosevich et
al. 1997).
Amniotic Membrane Transplantation
The amniotic membrane (AM) constitutes the inner wall of the fetal
membranes, and is a single layer of epithelium with an underlying stroma
rich in extra cellular matrix and collagens. As a fetal tissue it is considered
to be immunologically inert and to have several physiologic properties,
including induction of adhesion and migration of epithelial cells to reduce
infl ammatory, cicatricial, and angiogenic reactions (Dua et al. 2004).
Kim and Tseng reintroduced the AM in 1995 for ocular surface diseases
(Kim and Tseng 1995). Encouraging results led to a large and maybe over
expressed use in ophthalmology. Indications need to be clarifi ed and
compared in clinical trials to classical methods for a good evidence-based
medicine to evaluate its true potential.
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